The disappearance of Savannah Guthrie's mother is being treated as a "crime"

Speaking at a news conference on Monday (02.02.26), he said: "We do in fact have a crime scene. We do in fact have a crime. She did not leave on her own. We know that."

Nanos explained that law enforcement officials have been reviewing video footage from cameras at Nancy's home and has implored her neighbours to "go through their Ring cameras" as well.

The sheriff revealed that Guthrie needs to take medication on a daily basis and stressed that "it could be fatal" if she fails to do so.

He also explained that Nancy had "no cognitive issues" and would not have been able to leave the property alone because of mobility issues.

Nanos said: "This is not dementia-related. She's as sharp as a tack. The family wants everyone to know that this isn't someone who just wandered off.

"She couldn't walk 50 yards by herself."

The sheriff has asked members of the public to come forward if they have any information relating to the case.

He said: "I need this community to step up and start giving us some calls."

The sheriff's update comes after Savannah had urged "anyone with information" about Nancy's disappearance to contact the authorities.

The broadcaster - who did not appear on Today on Monday - said in a statement issued to the NBC morning show: "On behalf of our family, I want to thank everyone for the thoughts, prayers and messages of support.

"Right now, our focus remains on the safe return of our dear Nancy.

"We thank law enforcement for their hard work on this case, and encourage anyone with information to contact the Pima County Sheriff's Department."

Nanos had suggested on Sunday (01.02.26) that foul play couldn't be ruled out in Nancy's disappearance because of "concerning evidence", although he did not elaborate further.

He explained: "You don't typically get the sheriff out at a scene like this, but it's very concerning what we're learning from the house.

"This one stood out because of what was described to us at the scene and what we found and located just in looking at the scene."